Hair Loss

Hair Loss Treatment

Archives for: January 2010

Model for pattern lair loss

01/19/10 | by donnaproctorcom

| Categories: Hair loss treatment

Arch Dermatol Res. 1989;281:247

... The androchronogenetic alopecia (AGA) mouse as a model for male-pattern baldness.

Matias JR, et al

The AGA mouse expresses male pattern hair loss. Daily testosterone treatment induced hair thinning along the upper back. After 12 to 14 weeks this diffuse hair loss eventually eveloped into a bald area which extended to the middorsum. Dihydrotestosterone was more effective than T in stimulating the onset of pattern hair loss. In this model, T decreased the rate of hair growth, decreasing the duration of anagen, and markedly prolonging the duration of telogen. Topical cyproterone acetate delayed the progression of testosterone-mediated hair loss. However, this inhibitory effect occurred through systemic means as evidenced by decrease in the size of the submaxillary gland. Chronic feeding of androgen-treated female AGA mice with a diet containing 0.01% minoxidil also inhibited the development of hair loss..... Increasing the dose to 2% caused a slight retardation of the development of alopecia.....

Hair loss treatment in congenital hidrotic ectodermal dysplasia

01/03/10 | by donnaproctorcom

| Categories: Hair loss treatment

Int J Dermatol. 2009;48:184

Hair loss in congenital hidrotic ectodermal dysplasia responding to treatment with a combination of topical minoxidil and tretinoin.Melkote S, et al

Clouston's syndrome is an ectodermal dysplasia characterized by dystrophic nails, hair loss, and palmoplantar hyperkeratosis. hair loss is due to decrease in number and degree of maturation of the hair follicles. Tretinoin is a mitogen by itself and also enhances the absorption of minoxidil which acts by enlarging the miniaturized hair follicles. We report a case of alopecia in Clouston's syndrome who responded to treatment with topical minoxidil and tretinoin.

edited