Arch Dermatol Res.1989;281:247

Modified for hair loss treatment blog

The androchronogenetic alopecia mouse as a model for male-pattern hair loss.

Matias JR, et al

The AGA mouse expresses androgen-dependent baldness. Daily injection of testosterone (T) induced hair thinning. This diffuse hair loss eventually eveloped into a bald area which extended to the middorsum. Dihydrotestosterone was more effective than T in stimulating the onset of AGA. In this model, T produced the alopecia by decreasing the rate of hair regrowth, decreasing the duration of anagen, and markedly prolonging the duration of telogen. Cyproterone acetate delayed the progression of hair loss...... Chronic feeding of androgen-treated female AGA mice with a diet containing minoxidil also inhibited the development of hair loss. Skin and core temperatures were found to be higher in minoxidil-treated animals than in the placebo-treated controls. Minoxidil at a topical dose of 1% did not produce any effect. Increasing the dose to 2% caused a slight retardation of the development of alopecia. However, a 60% inhibition was observed at a topical dose of 5% minoxidil after 12 weeks of treatmen. The data demonstrate that hair loss in the AGA mouse is androgen dependent and that this mutant strain can serve as a suitable model for the screening of compounds, such as antiandrogens and vasodilators, which may influence the balding process.

Hair Loss blog