Model for pattern lair loss

Model for pattern lair loss

01/19/10 | by donnaproctorcom [mail] | Categories: Hair loss treatment

Arch Dermatol Res. 1989;281:247

... The androchronogenetic alopecia (AGA) mouse as a model for male-pattern baldness.

Matias JR, et al

The AGA mouse expresses male pattern hair loss. Daily testosterone treatment induced hair thinning along the upper back. After 12 to 14 weeks this diffuse hair loss eventually eveloped into a bald area which extended to the middorsum. Dihydrotestosterone was more effective than T in stimulating the onset of pattern hair loss. In this model, T decreased the rate of hair growth, decreasing the duration of anagen, and markedly prolonging the duration of telogen. Topical cyproterone acetate delayed the progression of testosterone-mediated hair loss. However, this inhibitory effect occurred through systemic means as evidenced by decrease in the size of the submaxillary gland. Chronic feeding of androgen-treated female AGA mice with a diet containing 0.01% minoxidil also inhibited the development of hair loss..... Increasing the dose to 2% caused a slight retardation of the development of alopecia.....

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